康氏立克次氏體IgG免疫熒光試劑盒

Rickettsia conorii IgG IFA Kit

廣州健侖生物科技有限公司

主要用途：用于檢測(cè)人血清中的康氏立克次氏體IgG抗體

產(chǎn)品規(guī)格：12 孔/張,10 張/盒

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康氏立克次氏體IgG免疫熒光試劑盒

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【公司名稱】 廣州健侖生物科技有限公司
【】    楊永漢 
【】 
【騰訊 】 2042552662
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號(hào)二期2幢101-3室
【企業(yè)文化】

在這項(xiàng)工作中，科學(xué)家提出了一個(gè)通用的模型發(fā)現(xiàn)，由2型轉(zhuǎn)谷氨酰胺酶的作用造成異常的IP3受體介導(dǎo)的鈣信號(hào)轉(zhuǎn)導(dǎo)，導(dǎo)致細(xì)胞功能紊亂，隨后出現(xiàn)大腦功能障礙。轉(zhuǎn)谷氨酰胺酶2的激活通常與炎癥和應(yīng)激有關(guān)，以及IP3通道上的轉(zhuǎn)谷氨酰胺酶2作用，可能會(huì)為常見于不同的神經(jīng)變性疾病的發(fā)生和發(fā)展步驟提供一個(gè)證據(jù)。
這項(xiàng)研究的*Katsuhiko Mikoshiba說(shuō)：“我們認(rèn)為，我們?cè)谶@項(xiàng)研究中所確定的機(jī)制，可以為我們提供一個(gè)研究大腦和身體的其他部位的其他疾病的通用模型，其中2型轉(zhuǎn)谷氨酰胺酶被上調(diào)。我們希望這種認(rèn)知zui終可能為許多神經(jīng)退行性疾病開發(fā)新的藥物療法，這些疾病為患者和社會(huì)帶來(lái)沉重的負(fù)擔(dān)。”
大約50年前，電子顯微鏡揭示了細(xì)胞內(nèi)形成的類似斑點(diǎn)的結(jié)構(gòu)，它們到處移動(dòng)然后消失。但科學(xué)家們并不知道它們存在的意義——據(jù)稱這些移動(dòng)的類似云的蛋白質(zhì)集合對(duì)細(xì)胞生命至關(guān)重要，因此它們或可能提供疾病治療的新方法。
在期刊《細(xì)胞生物學(xué)》上發(fā)表在一項(xiàng)研究里，兩名研究人員呼吁不同背景的科研者，從生物學(xué)到細(xì)胞生物學(xué)，將關(guān)注點(diǎn)集中在這些構(gòu)造的用途上，他們啟用了一個(gè)統(tǒng)一的術(shù)語(yǔ)“集合體”來(lái)指代它們。
“我想要了解尤文肉瘤里的這些集合體在做什么，尤文肉瘤是我正在關(guān)注研究的疾病，我認(rèn)為所有研究人體生物學(xué)的其他科研人員應(yīng)該也會(huì)想要知道集合體在健康人群和疾病人群里所發(fā)揮的功能。” 喬治敦倫巴狄綜合癌癥中心腫瘤學(xué)和兒科學(xué)學(xué)院的教授杰弗里·托雷茨基(Jeffrey Toretsky)這樣說(shuō)道。

In this work, scientists propose a generic model that found that aberrant IP3 receptor-mediated calcium signaling caused by type 2 transglutaminase leads to cellular dysfunction followed by brain dysfunction. Activation of transglutaminase 2, which is usually associated with inflammation and stress, and transglutaminase 2 action on the IP3 channel, may provide evidence of the common occurrence and progression of various neurodegenerative diseases.
Katsuhiko Mikoshiba, leader of the study, said: "We think the mechanism we identified in this study can provide us with a generic model for studying other diseases of the brain and other parts of the body, of which type 2 transglutaminase Amidase is up-regulated, and we hope this perception could ultimay lead to the development of new drug regimens for many neurodegenerative diseases that put a heavy burden on patients and society. "
About 50 years ago, electron microscopy revealed similar spots in the cell structure, they move around and disappear. But scientists do not know the meaning of their existence - these moving cloud-like protein collections are said to be vital to cell life and therefore they may or may provide new ways of treating the disease.
In a study published in the journal Cell Biology, two researchers called for researchers of diverse backgrounds, from biology to cell biology, to focus on the uses of these constructs, enabling a unified The term "aggregate" refers to them.
"I want to know what these assemblies in Ewing's sarcoma are doing, and Ewing's sarcoma is a disease I'm focusing on, and I think all other researchers working on human biology should also want to know how the aggregates are found in healthy people and diseases People, "said Jeffrey Toretsky, a professor at the Oncology and Paediatrics School at the Georgetown Comprehensive Cancer Center in Georgetown.